β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1
Identifieur interne : 000255 ( Main/Exploration ); précédent : 000254; suivant : 000256β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1
Auteurs : Li-Na Lv [République populaire de Chine] ; Xiao-Chao Wang [République populaire de Chine] ; Li-Ju Tao [République populaire de Chine] ; Hong-Wen Li [République populaire de Chine] ; Shu-You Li [République populaire de Chine] ; Fei-Meng Zheng [République populaire de Chine]Source :
- Cancer Cell International [ 1475-2867 ] ; 2019.
Abstract
Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and drug resistance. The β-Asarone, a low-toxicity compound from the traditional medical herb
Cell counting assay was used to evaluate Raji cell proliferation. CCK8 assay was used to evaluate the cell viability. Annexin-V/PI staining and flow cytometry analysis were used to evaluate apoptosis. ALDEFLUOR assay was used to evaluate the stem-like population. Luciferase reporter assay was used to examine the activation of NF-κB signaling. Western blot and polymerase chain reaction (PCR) were used to determine the expression of interested genes.
We showed that β-Asarone inhibited proliferation and induced apoptosis in Raji lymphoma cells in a dose-dependent manner. Additionally, β-Asarone functioned as a sensitizer of doxorubicin and resulted in synergistic effects on inhibition of proliferation and induction of apoptosis when combined with doxorubicin treatment. Interestingly, we found that β-Asarone also reduced the stem-like population of Raji lymphoma cells in a dose-dependent manner, and suppressed the expression of c-Myc and Bmi1. Importantly, β-Asarone abolished doxorubicin-induced enrichment of the stem-like population. In the mechanism study, we revealed that β-Asarone suppressed not only basal NF-κB activity but also Tumor necrosis factor α (TNF-α) induced NF-κB activity. Moreover, blocking NF-κB signaling inactivation was critical for β-Asarone induced apoptosis and inhibition of proliferation, but not for the effect on β-Asarone reduced stem-like population. In fact, β-Asarone suppressed stem-like population by destabilizing Bmi1 via a proteasome-mediated mechanism.
Our data suggested the application of β-Asarone to lower the toxic effect of doxorubicin and increase the sensitivity of doxorubicin in clinical treatment. More importantly, our data revealed a novel role of β-Asarone which could be used to eliminate stem-like population in lymphoma, implying that β-Asarone might reduce relapse and drug resistance.
The online version of this article (10.1186/s12935-019-0873-3) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12935-019-0873-3
PubMed: 31171917
PubMed Central: 6547485
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000048
- to stream Pmc, to step Curation: 000048
- to stream Pmc, to step Checkpoint: 000223
- to stream Ncbi, to step Merge: 000679
- to stream Ncbi, to step Curation: 000679
- to stream Ncbi, to step Checkpoint: 000679
- to stream Main, to step Merge: 000255
- to stream Main, to step Curation: 000255
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1</title>
<author><name sortKey="Lv, Li Na" sort="Lv, Li Na" uniqKey="Lv L" first="Li-Na" last="Lv">Li-Na Lv</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1798 2653</institution-id>
<institution-id institution-id-type="GRID">grid.256607.0</institution-id>
<institution>Department of Hematology,</institution>
<institution>Wuming Hospital of Guangxi Medical University,</institution>
</institution-wrap>
Nanning, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanning</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Xiao Chao" sort="Wang, Xiao Chao" uniqKey="Wang X" first="Xiao-Chao" last="Wang">Xiao-Chao Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tao, Li Ju" sort="Tao, Li Ju" uniqKey="Tao L" first="Li-Ju" last="Tao">Li-Ju Tao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Hong Wen" sort="Li, Hong Wen" uniqKey="Li H" first="Hong-Wen" last="Li">Hong-Wen Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Shu You" sort="Li, Shu You" uniqKey="Li S" first="Shu-You" last="Li">Shu-You Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1798 2653</institution-id>
<institution-id institution-id-type="GRID">grid.256607.0</institution-id>
<institution>Department of Medical Oncology,</institution>
<institution>Wuming Hospital of Guangxi Medical University,</institution>
</institution-wrap>
Nanning, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanning</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Fei Meng" sort="Zheng, Fei Meng" uniqKey="Zheng F" first="Fei-Meng" last="Zheng">Fei-Meng Zheng</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2360 039X</institution-id>
<institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution>Department of Medical Oncology of The Eastern Hospital, The First Affiliated Hospital,</institution>
<institution>Sun Yat-sen University,</institution>
</institution-wrap>
No. 58, Zhong Shan Er Lu, Guangzhou, 510080 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>No. 58, Zhong Shan Er Lu, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2360 039X</institution-id>
<institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution>Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital,</institution>
<institution>Sun Yat-sen University,</institution>
</institution-wrap>
Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31171917</idno>
<idno type="pmc">6547485</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547485</idno>
<idno type="RBID">PMC:6547485</idno>
<idno type="doi">10.1186/s12935-019-0873-3</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000048</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000048</idno>
<idno type="wicri:Area/Pmc/Curation">000048</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000048</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000223</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000223</idno>
<idno type="wicri:Area/Ncbi/Merge">000679</idno>
<idno type="wicri:Area/Ncbi/Curation">000679</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000679</idno>
<idno type="wicri:Area/Main/Merge">000255</idno>
<idno type="wicri:Area/Main/Curation">000255</idno>
<idno type="wicri:Area/Main/Exploration">000255</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1</title>
<author><name sortKey="Lv, Li Na" sort="Lv, Li Na" uniqKey="Lv L" first="Li-Na" last="Lv">Li-Na Lv</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1798 2653</institution-id>
<institution-id institution-id-type="GRID">grid.256607.0</institution-id>
<institution>Department of Hematology,</institution>
<institution>Wuming Hospital of Guangxi Medical University,</institution>
</institution-wrap>
Nanning, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanning</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Xiao Chao" sort="Wang, Xiao Chao" uniqKey="Wang X" first="Xiao-Chao" last="Wang">Xiao-Chao Wang</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tao, Li Ju" sort="Tao, Li Ju" uniqKey="Tao L" first="Li-Ju" last="Tao">Li-Ju Tao</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Hong Wen" sort="Li, Hong Wen" uniqKey="Li H" first="Hong-Wen" last="Li">Hong-Wen Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.460081.b</institution-id>
<institution>Department of Hematology,</institution>
<institution>Affiliated Hospital of Youjiang Medical University for Nationalities,</institution>
</institution-wrap>
Baise, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Baise</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Shu You" sort="Li, Shu You" uniqKey="Li S" first="Shu-You" last="Li">Shu-You Li</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1798 2653</institution-id>
<institution-id institution-id-type="GRID">grid.256607.0</institution-id>
<institution>Department of Medical Oncology,</institution>
<institution>Wuming Hospital of Guangxi Medical University,</institution>
</institution-wrap>
Nanning, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanning</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zheng, Fei Meng" sort="Zheng, Fei Meng" uniqKey="Zheng F" first="Fei-Meng" last="Zheng">Fei-Meng Zheng</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2360 039X</institution-id>
<institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution>Department of Medical Oncology of The Eastern Hospital, The First Affiliated Hospital,</institution>
<institution>Sun Yat-sen University,</institution>
</institution-wrap>
No. 58, Zhong Shan Er Lu, Guangzhou, 510080 China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>No. 58, Zhong Shan Er Lu, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2360 039X</institution-id>
<institution-id institution-id-type="GRID">grid.12981.33</institution-id>
<institution>Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital,</institution>
<institution>Sun Yat-sen University,</institution>
</institution-wrap>
Guangzhou, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangzhou</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer Cell International</title>
<idno type="eISSN">1475-2867</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and drug resistance. The β-Asarone, a low-toxicity compound from the traditional medical herb <italic>Acorus calamus</italic>
, has been shown to act as an anti-cancer reagent in various cancer types. However, the anti-cancer activities of β-Asarone in lymphoma have not been shown.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Cell counting assay was used to evaluate Raji cell proliferation. CCK8 assay was used to evaluate the cell viability. Annexin-V/PI staining and flow cytometry analysis were used to evaluate apoptosis. ALDEFLUOR assay was used to evaluate the stem-like population. Luciferase reporter assay was used to examine the activation of NF-κB signaling. Western blot and polymerase chain reaction (PCR) were used to determine the expression of interested genes.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">We showed that β-Asarone inhibited proliferation and induced apoptosis in Raji lymphoma cells in a dose-dependent manner. Additionally, β-Asarone functioned as a sensitizer of doxorubicin and resulted in synergistic effects on inhibition of proliferation and induction of apoptosis when combined with doxorubicin treatment. Interestingly, we found that β-Asarone also reduced the stem-like population of Raji lymphoma cells in a dose-dependent manner, and suppressed the expression of c-Myc and Bmi1. Importantly, β-Asarone abolished doxorubicin-induced enrichment of the stem-like population. In the mechanism study, we revealed that β-Asarone suppressed not only basal NF-κB activity but also Tumor necrosis factor α (TNF-α) induced NF-κB activity. Moreover, blocking NF-κB signaling inactivation was critical for β-Asarone induced apoptosis and inhibition of proliferation, but not for the effect on β-Asarone reduced stem-like population. In fact, β-Asarone suppressed stem-like population by destabilizing Bmi1 via a proteasome-mediated mechanism.</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">Our data suggested the application of β-Asarone to lower the toxic effect of doxorubicin and increase the sensitivity of doxorubicin in clinical treatment. More importantly, our data revealed a novel role of β-Asarone which could be used to eliminate stem-like population in lymphoma, implying that β-Asarone might reduce relapse and drug resistance.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (10.1186/s12935-019-0873-3) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thorn, Cf" uniqKey="Thorn C">CF Thorn</name>
</author>
<author><name sortKey="Oshiro, C" uniqKey="Oshiro C">C Oshiro</name>
</author>
<author><name sortKey="Marsh, S" uniqKey="Marsh S">S Marsh</name>
</author>
<author><name sortKey="Hernandez Boussard, T" uniqKey="Hernandez Boussard T">T Hernandez-Boussard</name>
</author>
<author><name sortKey="Mcleod, H" uniqKey="Mcleod H">H McLeod</name>
</author>
<author><name sortKey="Klein, Te" uniqKey="Klein T">TE Klein</name>
</author>
<author><name sortKey="Altman, Rb" uniqKey="Altman R">RB Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Batlle, E" uniqKey="Batlle E">E Batlle</name>
</author>
<author><name sortKey="Clevers, H" uniqKey="Clevers H">H Clevers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhattacharya, S" uniqKey="Bhattacharya S">S Bhattacharya</name>
</author>
<author><name sortKey="Muhammad, N" uniqKey="Muhammad N">N Muhammad</name>
</author>
<author><name sortKey="Steele, R" uniqKey="Steele R">R Steele</name>
</author>
<author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name>
</author>
<author><name sortKey="Ray, Rb" uniqKey="Ray R">RB Ray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhattacharya, S" uniqKey="Bhattacharya S">S Bhattacharya</name>
</author>
<author><name sortKey="Muhammad, N" uniqKey="Muhammad N">N Muhammad</name>
</author>
<author><name sortKey="Steele, R" uniqKey="Steele R">R Steele</name>
</author>
<author><name sortKey="Kornbluth, J" uniqKey="Kornbluth J">J Kornbluth</name>
</author>
<author><name sortKey="Ray, Rb" uniqKey="Ray R">RB Ray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muhammad, N" uniqKey="Muhammad N">N Muhammad</name>
</author>
<author><name sortKey="Steele, R" uniqKey="Steele R">R Steele</name>
</author>
<author><name sortKey="Isbell, Ts" uniqKey="Isbell T">TS Isbell</name>
</author>
<author><name sortKey="Philips, N" uniqKey="Philips N">N Philips</name>
</author>
<author><name sortKey="Ray, Rb" uniqKey="Ray R">RB Ray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Jp" uniqKey="Lin J">JP Lin</name>
</author>
<author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Hsieh, Wt" uniqKey="Hsieh W">WT Hsieh</name>
</author>
<author><name sortKey="Chung, Jg" uniqKey="Chung J">JG Chung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Constantinou, A" uniqKey="Constantinou A">A Constantinou</name>
</author>
<author><name sortKey="Mehta, R" uniqKey="Mehta R">R Mehta</name>
</author>
<author><name sortKey="Runyan, C" uniqKey="Runyan C">C Runyan</name>
</author>
<author><name sortKey="Rao, K" uniqKey="Rao K">K Rao</name>
</author>
<author><name sortKey="Vaughan, A" uniqKey="Vaughan A">A Vaughan</name>
</author>
<author><name sortKey="Moon, R" uniqKey="Moon R">R Moon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ribeiro, D" uniqKey="Ribeiro D">D Ribeiro</name>
</author>
<author><name sortKey="Freitas, M" uniqKey="Freitas M">M Freitas</name>
</author>
<author><name sortKey="Tome, Sm" uniqKey="Tome S">SM Tome</name>
</author>
<author><name sortKey="Silva, Am" uniqKey="Silva A">AM Silva</name>
</author>
<author><name sortKey="Laufer, S" uniqKey="Laufer S">S Laufer</name>
</author>
<author><name sortKey="Lima, Jl" uniqKey="Lima J">JL Lima</name>
</author>
<author><name sortKey="Fernandes, E" uniqKey="Fernandes E">E Fernandes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chellian, R" uniqKey="Chellian R">R Chellian</name>
</author>
<author><name sortKey="Pandy, V" uniqKey="Pandy V">V Pandy</name>
</author>
<author><name sortKey="Mohamed, Z" uniqKey="Mohamed Z">Z Mohamed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Hw" uniqKey="Lim H">HW Lim</name>
</author>
<author><name sortKey="Kumar, H" uniqKey="Kumar H">H Kumar</name>
</author>
<author><name sortKey="Kim, Bw" uniqKey="Kim B">BW Kim</name>
</author>
<author><name sortKey="More, Sv" uniqKey="More S">SV More</name>
</author>
<author><name sortKey="Kim, Iw" uniqKey="Kim I">IW Kim</name>
</author>
<author><name sortKey="Park, Ji" uniqKey="Park J">JI Park</name>
</author>
<author><name sortKey="Park, Sy" uniqKey="Park S">SY Park</name>
</author>
<author><name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name>
</author>
<author><name sortKey="Choi, Dk" uniqKey="Choi D">DK Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name>
</author>
<author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name>
</author>
<author><name sortKey="Yun, Bs" uniqKey="Yun B">BS Yun</name>
</author>
<author><name sortKey="Hwang, Bk" uniqKey="Hwang B">BK Hwang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fang, Yq" uniqKey="Fang Y">YQ Fang</name>
</author>
<author><name sortKey="Fang, Rm" uniqKey="Fang R">RM Fang</name>
</author>
<author><name sortKey="Fang, Gl" uniqKey="Fang G">GL Fang</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Fu, Sy" uniqKey="Fu S">SY Fu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, H" uniqKey="Dong H">H Dong</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Rong, H" uniqKey="Rong H">H Rong</name>
</author>
<author><name sortKey="Jin, M" uniqKey="Jin M">M Jin</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Shi, L" uniqKey="Shi L">L Shi</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Du, X" uniqKey="Du X">X Du</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Zhang, Xx" uniqKey="Zhang X">XX Zhang</name>
</author>
<author><name sortKey="Sun, Qm" uniqKey="Sun Q">QM Sun</name>
</author>
<author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name>
</author>
<author><name sortKey="Liu, Sl" uniqKey="Liu S">SL Liu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Zhou, Jy" uniqKey="Zhou J">JY Zhou</name>
</author>
<author><name sortKey="Zou, X" uniqKey="Zou X">X Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Tl" uniqKey="Wang T">TL Wang</name>
</author>
<author><name sortKey="Ouyang, Cs" uniqKey="Ouyang C">CS Ouyang</name>
</author>
<author><name sortKey="Lin, Lz" uniqKey="Lin L">LZ Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baeuerle, Pa" uniqKey="Baeuerle P">PA Baeuerle</name>
</author>
<author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staudt, Lm" uniqKey="Staudt L">LM Staudt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jost, Pj" uniqKey="Jost P">PJ Jost</name>
</author>
<author><name sortKey="Ruland, J" uniqKey="Ruland J">J Ruland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Ti" uniqKey="Lee T">TI Lee</name>
</author>
<author><name sortKey="Jenner, Rg" uniqKey="Jenner R">RG Jenner</name>
</author>
<author><name sortKey="Boyer, La" uniqKey="Boyer L">LA Boyer</name>
</author>
<author><name sortKey="Guenther, Mg" uniqKey="Guenther M">MG Guenther</name>
</author>
<author><name sortKey="Levine, Ss" uniqKey="Levine S">SS Levine</name>
</author>
<author><name sortKey="Kumar, Rm" uniqKey="Kumar R">RM Kumar</name>
</author>
<author><name sortKey="Chevalier, B" uniqKey="Chevalier B">B Chevalier</name>
</author>
<author><name sortKey="Johnstone, Se" uniqKey="Johnstone S">SE Johnstone</name>
</author>
<author><name sortKey="Cole, Mf" uniqKey="Cole M">MF Cole</name>
</author>
<author><name sortKey="Isono, K" uniqKey="Isono K">K Isono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ringrose, L" uniqKey="Ringrose L">L Ringrose</name>
</author>
<author><name sortKey="Paro, R" uniqKey="Paro R">R Paro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siddique, Hr" uniqKey="Siddique H">HR Siddique</name>
</author>
<author><name sortKey="Saleem, M" uniqKey="Saleem M">M Saleem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, Fm" uniqKey="Zheng F">FM Zheng</name>
</author>
<author><name sortKey="Long, Zj" uniqKey="Long Z">ZJ Long</name>
</author>
<author><name sortKey="Hou, Zj" uniqKey="Hou Z">ZJ Hou</name>
</author>
<author><name sortKey="Luo, Y" uniqKey="Luo Y">Y Luo</name>
</author>
<author><name sortKey="Xu, Lz" uniqKey="Xu L">LZ Xu</name>
</author>
<author><name sortKey="Xia, Jl" uniqKey="Xia J">JL Xia</name>
</author>
<author><name sortKey="Lai, Xj" uniqKey="Lai X">XJ Lai</name>
</author>
<author><name sortKey="Liu, Jw" uniqKey="Liu J">JW Liu</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Kamran, M" uniqKey="Kamran M">M Kamran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, F" uniqKey="Zheng F">F Zheng</name>
</author>
<author><name sortKey="Yue, C" uniqKey="Yue C">C Yue</name>
</author>
<author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="He, B" uniqKey="He B">B He</name>
</author>
<author><name sortKey="Cheng, W" uniqKey="Cheng W">W Cheng</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Yan, M" uniqKey="Yan M">M Yan</name>
</author>
<author><name sortKey="Long, Z" uniqKey="Long Z">Z Long</name>
</author>
<author><name sortKey="Qiu, W" uniqKey="Qiu W">W Qiu</name>
</author>
<author><name sortKey="Yuan, Z" uniqKey="Yuan Z">Z Yuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chou, Tc" uniqKey="Chou T">TC Chou</name>
</author>
<author><name sortKey="Motzer, Rj" uniqKey="Motzer R">RJ Motzer</name>
</author>
<author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name>
</author>
<author><name sortKey="Bosl, Gj" uniqKey="Bosl G">GJ Bosl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohammad, N" uniqKey="Mohammad N">N Mohammad</name>
</author>
<author><name sortKey="Singh, Sv" uniqKey="Singh S">SV Singh</name>
</author>
<author><name sortKey="Malvi, P" uniqKey="Malvi P">P Malvi</name>
</author>
<author><name sortKey="Chaube, B" uniqKey="Chaube B">B Chaube</name>
</author>
<author><name sortKey="Athavale, D" uniqKey="Athavale D">D Athavale</name>
</author>
<author><name sortKey="Vanuopadath, M" uniqKey="Vanuopadath M">M Vanuopadath</name>
</author>
<author><name sortKey="Nair, Ss" uniqKey="Nair S">SS Nair</name>
</author>
<author><name sortKey="Nair, B" uniqKey="Nair B">B Nair</name>
</author>
<author><name sortKey="Bhat, Mk" uniqKey="Bhat M">MK Bhat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toledo Guzman, Me" uniqKey="Toledo Guzman M">ME Toledo-Guzman</name>
</author>
<author><name sortKey="Ibanez Hernandez, M" uniqKey="Ibanez Hernandez M">M Ibanez Hernandez</name>
</author>
<author><name sortKey="Gomez Gallegos, Aa" uniqKey="Gomez Gallegos A">AA Gomez-Gallegos</name>
</author>
<author><name sortKey="Ortiz Sanchez, E" uniqKey="Ortiz Sanchez E">E Ortiz-Sanchez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthews, Gm" uniqKey="Matthews G">GM Matthews</name>
</author>
<author><name sortKey="De Matos Simoes, R" uniqKey="De Matos Simoes R">R de Matos Simoes</name>
</author>
<author><name sortKey="Dhimolea, E" uniqKey="Dhimolea E">E Dhimolea</name>
</author>
<author><name sortKey="Sheffer, M" uniqKey="Sheffer M">M Sheffer</name>
</author>
<author><name sortKey="Gandolfi, S" uniqKey="Gandolfi S">S Gandolfi</name>
</author>
<author><name sortKey="Dashevsky, O" uniqKey="Dashevsky O">O Dashevsky</name>
</author>
<author><name sortKey="Sorrell, Jd" uniqKey="Sorrell J">JD Sorrell</name>
</author>
<author><name sortKey="Mitsiades, Cs" uniqKey="Mitsiades C">CS Mitsiades</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christian, Frank" uniqKey="Christian F">Frank Christian</name>
</author>
<author><name sortKey="Smith, Emma" uniqKey="Smith E">Emma Smith</name>
</author>
<author><name sortKey="Carmody, Ruaidhri" uniqKey="Carmody R">Ruaidhrí Carmody</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name>
</author>
<author><name sortKey="Negi, G" uniqKey="Negi G">G Negi</name>
</author>
<author><name sortKey="Sharma, Ss" uniqKey="Sharma S">SS Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annett, S" uniqKey="Annett S">S Annett</name>
</author>
<author><name sortKey="Robson, T" uniqKey="Robson T">T Robson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirsch, Ha" uniqKey="Hirsch H">HA Hirsch</name>
</author>
<author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D Iliopoulos</name>
</author>
<author><name sortKey="Tsichlis, Pn" uniqKey="Tsichlis P">PN Tsichlis</name>
</author>
<author><name sortKey="Struhl, K" uniqKey="Struhl K">K Struhl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Pb" uniqKey="Gupta P">PB Gupta</name>
</author>
<author><name sortKey="Onder, Tt" uniqKey="Onder T">TT Onder</name>
</author>
<author><name sortKey="Jiang, G" uniqKey="Jiang G">G Jiang</name>
</author>
<author><name sortKey="Tao, K" uniqKey="Tao K">K Tao</name>
</author>
<author><name sortKey="Kuperwasser, C" uniqKey="Kuperwasser C">C Kuperwasser</name>
</author>
<author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name>
</author>
<author><name sortKey="Lander, Es" uniqKey="Lander E">ES Lander</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Korkaya, H" uniqKey="Korkaya H">H Korkaya</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Lee, Hf" uniqKey="Lee H">HF Lee</name>
</author>
<author><name sortKey="Newman, B" uniqKey="Newman B">B Newman</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name>
</author>
<author><name sortKey="Clouthier, Sg" uniqKey="Clouthier S">SG Clouthier</name>
</author>
<author><name sortKey="Schwartz, Sj" uniqKey="Schwartz S">SJ Schwartz</name>
</author>
<author><name sortKey="Wicha, Ms" uniqKey="Wicha M">MS Wicha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name>
</author>
<author><name sortKey="Kallifatidis, G" uniqKey="Kallifatidis G">G Kallifatidis</name>
</author>
<author><name sortKey="Baumann, B" uniqKey="Baumann B">B Baumann</name>
</author>
<author><name sortKey="Rausch, V" uniqKey="Rausch V">V Rausch</name>
</author>
<author><name sortKey="Mattern, J" uniqKey="Mattern J">J Mattern</name>
</author>
<author><name sortKey="Gladkich, J" uniqKey="Gladkich J">J Gladkich</name>
</author>
<author><name sortKey="Giese, N" uniqKey="Giese N">N Giese</name>
</author>
<author><name sortKey="Moldenhauer, G" uniqKey="Moldenhauer G">G Moldenhauer</name>
</author>
<author><name sortKey="Wirth, T" uniqKey="Wirth T">T Wirth</name>
</author>
<author><name sortKey="Buchler, Mw" uniqKey="Buchler M">MW Buchler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Qin, Jj" uniqKey="Qin J">JJ Qin</name>
</author>
<author><name sortKey="Voruganti, S" uniqKey="Voruganti S">S Voruganti</name>
</author>
<author><name sortKey="Nag, S" uniqKey="Nag S">S Nag</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
<author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schuettengruber, B" uniqKey="Schuettengruber B">B Schuettengruber</name>
</author>
<author><name sortKey="Bourbon, Hm" uniqKey="Bourbon H">HM Bourbon</name>
</author>
<author><name sortKey="Di Croce, L" uniqKey="Di Croce L">L Di Croce</name>
</author>
<author><name sortKey="Cavalli, G" uniqKey="Cavalli G">G Cavalli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, H" uniqKey="Cui H">H Cui</name>
</author>
<author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
<author><name sortKey="Li, T" uniqKey="Li T">T Li</name>
</author>
<author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
<author><name sortKey="Alam, G" uniqKey="Alam G">G Alam</name>
</author>
<author><name sortKey="Gunning, Wt" uniqKey="Gunning W">WT Gunning</name>
</author>
<author><name sortKey="Ding, Hf" uniqKey="Ding H">HF Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dimri, Gp" uniqKey="Dimri G">GP Dimri</name>
</author>
<author><name sortKey="Martinez, Jl" uniqKey="Martinez J">JL Martinez</name>
</author>
<author><name sortKey="Jacobs, Jj" uniqKey="Jacobs J">JJ Jacobs</name>
</author>
<author><name sortKey="Keblusek, P" uniqKey="Keblusek P">P Keblusek</name>
</author>
<author><name sortKey="Itahana, K" uniqKey="Itahana K">K Itahana</name>
</author>
<author><name sortKey="Van Lohuizen, M" uniqKey="Van Lohuizen M">M Van Lohuizen</name>
</author>
<author><name sortKey="Campisi, J" uniqKey="Campisi J">J Campisi</name>
</author>
<author><name sortKey="Wazer, De" uniqKey="Wazer D">DE Wazer</name>
</author>
<author><name sortKey="Band, V" uniqKey="Band V">V Band</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Venugopal, C" uniqKey="Venugopal C">C Venugopal</name>
</author>
<author><name sortKey="Manoranjan, B" uniqKey="Manoranjan B">B Manoranjan</name>
</author>
<author><name sortKey="Mcfarlane, N" uniqKey="Mcfarlane N">N McFarlane</name>
</author>
<author><name sortKey="O Arrell, E" uniqKey="O Arrell E">E O’Farrell</name>
</author>
<author><name sortKey="Nolte, S" uniqKey="Nolte S">S Nolte</name>
</author>
<author><name sortKey="Gunnarsson, T" uniqKey="Gunnarsson T">T Gunnarsson</name>
</author>
<author><name sortKey="Hollenberg, R" uniqKey="Hollenberg R">R Hollenberg</name>
</author>
<author><name sortKey="Kwiecien, J" uniqKey="Kwiecien J">J Kwiecien</name>
</author>
<author><name sortKey="Northcott, P" uniqKey="Northcott P">P Northcott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Hua, R" uniqKey="Hua R">R Hua</name>
</author>
<author><name sortKey="Gan, L" uniqKey="Gan L">L Gan</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Ni, S" uniqKey="Ni S">S Ni</name>
</author>
<author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagamitsu, A" uniqKey="Nagamitsu A">A Nagamitsu</name>
</author>
<author><name sortKey="Greish, K" uniqKey="Greish K">K Greish</name>
</author>
<author><name sortKey="Maeda, H" uniqKey="Maeda H">H Maeda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Curnis, F" uniqKey="Curnis F">F Curnis</name>
</author>
<author><name sortKey="Sacchi, A" uniqKey="Sacchi A">A Sacchi</name>
</author>
<author><name sortKey="Corti, A" uniqKey="Corti A">A Corti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stohrer, M" uniqKey="Stohrer M">M Stohrer</name>
</author>
<author><name sortKey="Boucher, Y" uniqKey="Boucher Y">Y Boucher</name>
</author>
<author><name sortKey="Stangassinger, M" uniqKey="Stangassinger M">M Stangassinger</name>
</author>
<author><name sortKey="Jain, Rk" uniqKey="Jain R">RK Jain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morris, Me" uniqKey="Morris M">ME Morris</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohammad, N" uniqKey="Mohammad N">N Mohammad</name>
</author>
<author><name sortKey="Malvi, P" uniqKey="Malvi P">P Malvi</name>
</author>
<author><name sortKey="Meena, As" uniqKey="Meena A">AS Meena</name>
</author>
<author><name sortKey="Singh, Sv" uniqKey="Singh S">SV Singh</name>
</author>
<author><name sortKey="Chaube, B" uniqKey="Chaube B">B Chaube</name>
</author>
<author><name sortKey="Vannuruswamy, G" uniqKey="Vannuruswamy G">G Vannuruswamy</name>
</author>
<author><name sortKey="Kulkarni, Mj" uniqKey="Kulkarni M">MJ Kulkarni</name>
</author>
<author><name sortKey="Bhat, Mk" uniqKey="Bhat M">MK Bhat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paranjape, An" uniqKey="Paranjape A">AN Paranjape</name>
</author>
<author><name sortKey="Balaji, Sa" uniqKey="Balaji S">SA Balaji</name>
</author>
<author><name sortKey="Mandal, T" uniqKey="Mandal T">T Mandal</name>
</author>
<author><name sortKey="Krushik, Ev" uniqKey="Krushik E">EV Krushik</name>
</author>
<author><name sortKey="Nagaraj, P" uniqKey="Nagaraj P">P Nagaraj</name>
</author>
<author><name sortKey="Mukherjee, G" uniqKey="Mukherjee G">G Mukherjee</name>
</author>
<author><name sortKey="Rangarajan, A" uniqKey="Rangarajan A">A Rangarajan</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Guangdong</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Lv, Li Na" sort="Lv, Li Na" uniqKey="Lv L" first="Li-Na" last="Lv">Li-Na Lv</name>
</noRegion>
<name sortKey="Li, Hong Wen" sort="Li, Hong Wen" uniqKey="Li H" first="Hong-Wen" last="Li">Hong-Wen Li</name>
<name sortKey="Li, Shu You" sort="Li, Shu You" uniqKey="Li S" first="Shu-You" last="Li">Shu-You Li</name>
<name sortKey="Tao, Li Ju" sort="Tao, Li Ju" uniqKey="Tao L" first="Li-Ju" last="Tao">Li-Ju Tao</name>
<name sortKey="Wang, Xiao Chao" sort="Wang, Xiao Chao" uniqKey="Wang X" first="Xiao-Chao" last="Wang">Xiao-Chao Wang</name>
<name sortKey="Zheng, Fei Meng" sort="Zheng, Fei Meng" uniqKey="Zheng F" first="Fei-Meng" last="Zheng">Fei-Meng Zheng</name>
<name sortKey="Zheng, Fei Meng" sort="Zheng, Fei Meng" uniqKey="Zheng F" first="Fei-Meng" last="Zheng">Fei-Meng Zheng</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000255 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000255 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6547485 |texte= β-Asarone increases doxorubicin sensitivity by suppressing NF-κB signaling and abolishes doxorubicin-induced enrichment of stem-like population by destabilizing Bmi1 }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31171917" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |